Article: Open-source platform using gene therapy to find a cure for kids with rare diseases

Cures, Drugs, Open Health, Procedures (Medical)

Open-source platform using gene therapy to find a cure for kids with rare diseases

The genetic condition that affects Raghav is called Sedaghatian type Spondylometaphyseal Dysplasia (SSMD). SSMD causes cardiac arrhythmia and abnormalities in the skeletal and central nervous system. Doctors said Raghav would be a wheelchair user, non-verbal and likely to die prematurely. A diagnosis that Ramesh, a software engineer with Amazon, and his wife were unwilling to accept.

Along with his work at Amazon, Ramesh started Googling for information regarding the genetic condition that was affecting his son and read up all the relevant literature regarding gene therapy and other treatments that were available on this rare disease.

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Article: What’s a Better Way To Finance Drug Dev – Open Source or Patent Financing?

Drugs, Open Health, Open Source

What’s a Better Way To Finance Drug Dev – Open Source or Patent Financing?

It is often said that intellectuals have a hard time dealing with new ideas. Unfortunately, for purposes of public debate, open-source government funding of drug development is a new idea, and people in policy positions seem to be having a very hard time understanding it. So, I will try to write this post in a way that even a policy wonk can figure it out.

The basic idea of government-funded research should not be hard to grasp since the government already funds a large share of biomedical research. The National Institutes of Health gets over $40 billion a year in federal funding, with the Biomedical Advanced Research and Development Agency (BARDA) and other government agencies getting several billion more.

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Article: Open-Source Design for a Biodegradable Prescription Pill Bottle Made from Paper

Design, Open Space

Open-Source Design for a Biodegradable Prescription Pill Bottle Made from Paper

For those taking prescription medications, plastic is likely the only vessel they come in–and some 90% of them are not recycled, according to Tikkun Olam Makers, an Israel-based collective dedicated to solving social and environmental problems. Thus they’ve created the Prescription Paper Pill Bottle:

The Prescription Paper Pill Bottle, a first of its kind, is 100% compostable and biodegradable. Its open-source design adheres to FDA regulations for durability, light, water, and child resistance. It’s available to any pharmacy for filling prescription tablets and capsules.

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Article: Children Synthesize Two Dollar Version of Martin Shkreli’s $750 Malaria Drug

Drugs, Materials, Open Health, Open Manufacturing, Open Source

Children Synthesize Two Dollar Version of Martin Shkreli’s $750 Malaria Drug

On 30 November 2016, the Sydney Morning Herald reported on a of a class of high school boys from the Sydney Grammar School, who (as part of a collaboration with university scientists) synthesized pyrimethamine, the active ingredient in the drug Daraprim (once used as an antimalarial, now primarily used to treat toxoplasmosis and cystoisosporiasis).

Daraprim gained notoriety in September 2015, when Turing Pharmaceuticals (then run by Martin Shkreli) purchased the rights to its distribution and raised its price from $13.50 a tablet to $750.00.

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