Article: Open-source platform using gene therapy to find a cure for kids with rare diseases

Cures, Drugs, Open Health, Procedures (Medical)

Open-source platform using gene therapy to find a cure for kids with rare diseases

The genetic condition that affects Raghav is called Sedaghatian type Spondylometaphyseal Dysplasia (SSMD). SSMD causes cardiac arrhythmia and abnormalities in the skeletal and central nervous system. Doctors said Raghav would be a wheelchair user, non-verbal and likely to die prematurely. A diagnosis that Ramesh, a software engineer with Amazon, and his wife were unwilling to accept.

Along with his work at Amazon, Ramesh started Googling for information regarding the genetic condition that was affecting his son and read up all the relevant literature regarding gene therapy and other treatments that were available on this rare disease.

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Article: A redux of the Linux movement in open source pharma

Drugs, Open Health

A redux of the Linux movement in open source pharma

Thirty years ago, a 21-year-old student at the University of Helsinki put out a message on a bulletin board, “i am doing a (free) operating system (just a hobby, won’t be big or professional..),” and asked for feedback.

Little did he know that these few words would be the beginning of a gigantic revolution that would transform digital life around the world. This was the birth of the free operating system that came to be known as Linux, named after the kid, Linus Torvalds, who invented it.

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Article: Open Source Joins Efforts to Create Gene Therapies for Rare Diseases

Cures, Drugs, Open Health, Procedures (Medical)

Open Source Joins Efforts to Create Gene Therapies for Rare Diseases

Some 400 million patients worldwide are affected by more than 7,000 rare diseases; yet treatments for rare genetic diseases remain an underserved area. More than 95 percent of rare diseases do not have an approved treatment, and new treatments are estimated to cost more than $1 billion.

Sanath Ramesh created the RareCamp project and the OpenTreatments Foundation to enable patients to create gene therapies for rare genetic diseases and then work with their doctors and nonprofit organizations to develop drugs. The Linux Foundation, the nonprofit organization enabling mass innovation through open source, is helping those efforts succeed.

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Article: Why The 21st Century Cures Act is an Innovators Dream

API, Cures, Drugs, Open Health, Open Infrastructure, Procedures (Medical)

Why The 21st Century Cures Act is an Innovators Dream

Designed largely to accelerate medical product development and get new medications and treatments through the development process faster, the 21st Century Cures Act is a significant piece of legislation that  passed in 2016.

Some of its provisions are also meant to empower patients with more information about their own . The ONC Cures Act Final Rule in particular — which will go into effect in April of this year — says that providers must make patients’ electronic health records (EHRs) available to them. This means that data is unequivocally going to be in the hands of patients. It means better care for patients, but it also means that a whole new set of services and innovations will be possible.

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Article: Houston researchers tap into tech to provide new brain-related health care solutions

Cures, Drugs, Open Health, Procedures (Medical)

Houston researchers tap into tech to provide new brain-related health care solutions

A University of Houston researcher is tapping into technology to better treat brain injuries and conditions that scientists have not yet figured out treatment for. Badri Roysam, the current chair of electrical and computer engineering at UH and a Hugh Roy and Lillie Cranz Cullen University Professor, and his team have created a new computational image analysis methods based on deep neural networks.

“We are interested in mapping and profiling unhealthy and drug-treated brain tissue in unprecedented detail to reveal multiple biological processes at once – in context,” Roysam says in a UH press release about his latest paper published in Nature Communications. “This requires the ability to record high-resolution images of brain tissue covering a comprehensive panel of molecular biomarkers, over a large spatial extent, e.g., whole-brain slices, and automated ability to generate quantitative readouts of biomarker expression for all cells.”

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Article: AI Predicts Effective Drug Combinations to Fight Complex Diseases Faster

Cures, Drugs, Open Health, Procedures (Medical)

AI Predicts Effective Drug Combinations to Fight Complex Diseases Faster

Finding new ways to repurpose or combine existing drugs has proved to be a powerful tool to treat complex diseases. Drugs used to treat one type of cancer, for instance, have effectively strengthened treatments for other cancer cells. Complex malignant tumors often require a combination of drugs or “drug cocktails,” to formulate a concerted attack on multiple cell types. Drug cocktails can not only help stave off drug resistance but also minimize harmful side effects.

But finding an effective combination of existing drugs at the right dose is extremely challenging, partly because there are near-infinite possibilities.

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Article: Linux Foundation sigstore finds ‘origins’ in software supply chains

Cures, Drugs, Open Health, Procedures (Medical)

Linux Foundation sigstore finds ‘origins’ in software supply chains

Zuellig Pharma’s eZTracker leverages blockchain to help countries get up to speed with their vaccination programmes and to counter the threat of counterfeit vaccines. Take a peek behind the curtain and learn how the smartphone app, powered by SAP’s blockchain platform, lets consumers verify the authenticity of a drug.

Designed to improves the security of the software supply chain, sigstore is said to enable the adoption of cryptographic software signing backed by transparency log technologies. Software application development professionals will be able to securely sign software artifacts such as release files, container images and binaries.

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Article: What’s a Better Way To Finance Drug Dev – Open Source or Patent Financing?

Drugs, Open Health, Open Source

What’s a Better Way To Finance Drug Dev – Open Source or Patent Financing?

It is often said that intellectuals have a hard time dealing with new ideas. Unfortunately, for purposes of public debate, open-source government funding of drug development is a new idea, and people in policy positions seem to be having a very hard time understanding it. So, I will try to write this post in a way that even a policy wonk can figure it out.

The basic idea of government-funded research should not be hard to grasp since the government already funds a large share of biomedical research. The National Institutes of Health gets over $40 billion a year in federal funding, with the Biomedical Advanced Research and Development Agency (BARDA) and other government agencies getting several billion more.

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Article: Open-Source Toolkit Developed on University of Houston Supercomputer Accelerates Drug Development

Drugs, Open Health, Open Software, Open Source

Open-Source Toolkit Developed on University of Houston Supercomputer Accelerates Drug Development

Though 40 million concussions are recorded annually, no effective treatment exists for them or for many other brain-related illnesses. In collaboration with Dragan Maric of the National Institutes of Health, Badri Roysam, Hugh Roy and Lillie Cranz Cullen University Professor and Chair of Electrical and Computer Engineering, and his team are working to speed up drug development to treat brain diseases and injuries like concussion by developing new tools. 

We are interested in mapping and profiling unhealthy and drug-treated brain tissue in unprecedented detail to reveal multiple biological processes at once – in context,”

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Article: The Importance of Data Collection in Healthcare

Cures, Drugs, Open Health, Procedures (Medical)

The Importance of Data Collection in Healthcare

Decision-making should be based on facts, regardless of industry. The importance of data collection and its analysis leveraging Big Data technologies has demonstrated that the more accurate the information gathered, the sounder the decisions made, and the better the results that can be achieved.

Medicine is that very industry that is greatly influenced and altered by Big Data. Read our article if you want to learn about the importance of data collection in healthcare and the tools that are used to collect information and turn it into business value.

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